MIRARI® Cold Plasma System

The world's
first handheld
cold plasma device

An FDA-cleared, dual-modality therapeutic platform — designed for clinical professionals.

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FDA 510(k) ClearedUnited States
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Thai FDA ApprovedThailand
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MOH RegisteredVietnam
MIRARI Cold Plasma Device

Built for the Clinical Environment

Portable handheld design
IEC 60601-1 & IEC 60601-1-2 Compliant
USB-C fast charging
Non-invasive therapy
DBD plasma technology
Thermal regulation technology

Discover the MIRARI® Difference

Watch how the world's first handheld cold plasma device is transforming clinical practices.

Discover the MIRARI® Difference

Two Modes. One Platform.

The MIRARI® Cold Plasma System operates on a dual-modality architecture, combining Radio frequency energy generator delivery in a single handheld device.

CAP and RES Modes Diagram
CAP MODE
CAP Mode

Surface Tissue Therapy

Targets superficial tissues with high water content, such as skin and soft tissue. In CAP mode, the device generates cold atmospheric plasma via Dielectric Barrier Discharge (DBD), delivering reactive oxygen and nitrogen species directly to the tissue surface.

  • Cold plasma via DBD
  • Delivers ROS, RNS, and NO
  • Surface-level applications
RES MODE
RES Mode

Deep Tissue Therapy

Targets deeper, denser structures, such as tendons, ligaments, and joint capsules. In RES mode, 80 kHz monopolar radiofrequency energy is converted into controlled thermal energy as it encounters tissue resistance.

  • 80 kHz monopolar RF
  • Converts to thermal energy
  • Deep-tissue applications
CAP Mode

Surface Tissue Therapy

Targets superficial tissues with high water content, such as skin and soft tissue. In CAP mode, the device generates cold atmospheric plasma via Dielectric Barrier Discharge (DBD), delivering reactive oxygen and nitrogen species directly to the tissue surface.

  • Cold plasma via DBD
  • Delivers ROS, RNS, and NO
  • Surface-level applications
RES Mode

Deep Tissue Therapy

Targets deeper, denser structures, such as tendons, ligaments, and joint capsules. In RES mode, 80 kHz monopolar radiofrequency energy is converted into controlled thermal energy as it encounters tissue resistance.

  • 80 kHz monopolar RF
  • Converts to thermal energy
  • Deep-tissue applications
Both CAP and RES modes operate simultaneously in every treatment session
delivering controlled RF energy heating across the treatment area in a single application.

What's Inside the MIRARI® System

Plasma Driver

Plasma Driver

  • Rechargeable handheld unit — two 18650 LiFePO4 battery cells
  • Immune to thermal runaway — inherent fire safety
  • Fast-acting fuse protection
  • USB-C charging (5V, 2.4A recommended)
  • LED indicator: Red (charging) / Green (charged)
Plasma Array (Consumable)

Plasma Array (Consumable)

  • High-voltage, low-current Dielectric Barrier Discharge
  • Interconnected tip pattern concentrates electric field
  • IEC 60601-1 Type B classification — no current passes through patient
  • ~80 treatment sessions per array (15 mins/session)
Insulating Fleece Pouch

Insulating Fleece Pouch

  • Only component in direct contact with patient skin
  • Distributes heat uniformly — surface temp ≤ 45°C
  • Waterproof ePTFE membrane — allows airflow, blocks liquid
  • Absorbs residual ozone for patient safety
Magnetic Connector Cable

Magnetic Connector Cable

  • 3.5 mm audio jack with custom-molded cable
  • Magnetic locking mechanism for secure array connection
  • Supports authentication between Array and Driver
15 mins
Treatment Time
20 hours
Continuous Battery Life
~80
Sessions per Array
3 years
Device Lifespan (2400 sessions)

Clinical Specialties

Pain Management
Pain Management
Temporary relief of pain for selected medical conditions
Muscle & Rehabilitation
Muscle & Rehabilitation
Temporary relief of muscle spasms
Circulatory Therapy
Circulatory Therapy
Increase in local circulation through tissue temperature elevation

Approved Certifications

Rigorous compliance across biological safety, risk management, and device performance.

ISO 10993-1
ISO 10993-1
ISO 10993-2
ISO 10993-2
ISO 10993-5
ISO 10993-5
ISO 10993-10
ISO 10993-10
ISO 10993-12
ISO 10993-12
ISO 60601-1
ISO 60601-1
ISO 60601-2-2
ISO 60601-2-2
ISO 17050-1
ISO 17050-1
ISO 14971
ISO 14971
ASTM D4169
ASTM D4169
IEC 62133
IEC 62133
UN 38.3
UN 38.3
UL 867
UL 867
FDA GLP
FDA GLP
ISTA 2A
ISTA 2A

Patents

Developed over years of dedicated research, our granted U.S. patents represent the intellectual foundation of MIRARI® — protecting innovations that took decades of scientific expertise to achieve.

Patent